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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , <t>TYK2</t> and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.
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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , <t>TYK2</t> and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.
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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , <t>TYK2</t> and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.
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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , <t>TYK2</t> and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.
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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , <t>TYK2</t> and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.
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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , <t>TYK2</t> and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.
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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , <t>TYK2</t> and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.
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Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , TYK2 and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.

Journal: Frontiers in Immunology

Article Title: Modulation of TLR7 , TYK2 and OAS1 expression during SARS-CoV-2 infection

doi: 10.3389/fimmu.2025.1713928

Figure Lengend Snippet: Gene expression modulation according to COVID-19 severity groups (A) and over time (B) . Data adjusted for plate number and days from symptom onset to extraction date. (A) TLR7 , TYK2 and OAS1 expression grouped by COVID-19 severity (mild [blue], moderate [yellow] and severe [red]) for each extraction. The boxes represent the median (line) with interquartile range. Statistics: Kruskal-Wallis and Dunn test. (B) Linear regression of TLR7 , TYK2 and OAS1 expression over days from symptom onset to extraction date, grouped by severity levels reported at extraction time. Bold: significant p -values.

Article Snippet: Predesigned TaqManTM assays used were: Hs00152971_m1 ( TLR7 ), Hs00177464_m1 ( TYK2 ), Hs00973635_m1 ( OAS1 ), and Hs02800695_m1 ( HPRT ) and Hs00427620_m1 ( TBP ) as housekeeping genes.

Techniques: Gene Expression, Extraction, Expressing

Forest plots of the multivariate analysis of TLR7 (A) , OAS1 (B) and TYK2 (C) expression. The multivariate model was adjusted for plate number and days from symptom onset to extraction date. The plot represents beta-coefficient (dots and numbers) with 95% confidence intervals (horizontal bars) for the significant variables in the model. * p ≤ 0.1; ** p ≤ 0.05; *** p ≤ 0.01.

Journal: Frontiers in Immunology

Article Title: Modulation of TLR7 , TYK2 and OAS1 expression during SARS-CoV-2 infection

doi: 10.3389/fimmu.2025.1713928

Figure Lengend Snippet: Forest plots of the multivariate analysis of TLR7 (A) , OAS1 (B) and TYK2 (C) expression. The multivariate model was adjusted for plate number and days from symptom onset to extraction date. The plot represents beta-coefficient (dots and numbers) with 95% confidence intervals (horizontal bars) for the significant variables in the model. * p ≤ 0.1; ** p ≤ 0.05; *** p ≤ 0.01.

Article Snippet: Predesigned TaqManTM assays used were: Hs00152971_m1 ( TLR7 ), Hs00177464_m1 ( TYK2 ), Hs00973635_m1 ( OAS1 ), and Hs02800695_m1 ( HPRT ) and Hs00427620_m1 ( TBP ) as housekeeping genes.

Techniques: Expressing, Extraction